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Proposed model for age-related changes linking oxidative stress with increased miR-34a-5p expression and Malat1 inhibition. Activation of p53 both stimulates miR-34a and suppresses MALAT1, which creates a feed-forward cycle further increasing miR-34a levels. Elevated mir-34a targets Sirt1 which can increase senescence as well as TGF-β1, increases fibrosis. Together these factors are likely to impair muscle function with aging.
