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. 2022 Jan 21;12:803102. doi: 10.3389/fphys.2021.803102

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Copyright © 2022 You, Yu, Li, He and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meta-analysis of the effects of different intensities of aerobic exercise on the FMD in healthy middle-aged and elderly people. The pooled estimates were obtained from random effects analysis. Diamonds indicated the effect size of each study summarized as WMD. The size of the shaded squares was proportional to the percentage weight of each study. Horizontal lines represented the 95% CI and the vertical line represented the overall effect. Moderate-intensity aerobic exercise had no significant relationship with FMD in the middle-aged and elderly people [WMD, 1.49 (95% CI, −0.62 to 3.60), P = 0.17], while vigorous-intensity aerobic exercise improved FMD significantly [WMD, 1.10 (95% CI, 0.27–1.93), P < 0.05].