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. 2022 Jan 21;12:762998. doi: 10.3389/fphar.2021.762998

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Copyright © 2022 Ding, Li, Yang, Song, Qi, Wang, Wang, Zhao, Zhang, Zhao, Zhao, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The main active components and good reproducibility of the WBT formula were determined by UHPLC/Q-TOF-MS analysis. (A,B) The chromatograms of the WBT formula for 42 active components in positive and negative ion modes. Blue numbers represent the compounds confirmed with the reference standards. (C and D) The reproducible HPLC fingerprints of the 10 batches of WBT (S1–S10) were identified using the Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine (2004 Edition).