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. 2022 Jan 21;12:762998. doi: 10.3389/fphar.2021.762998

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Copyright © 2022 Ding, Li, Yang, Song, Qi, Wang, Wang, Zhao, Zhang, Zhao, Zhao, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WBT formula attenuated BLM-induced lung fibrosis after 14-day treatment. (A) H&E and Masson’s trichrome stainings for the lung tissues from Ctrl, Sham, BLM, BLM + WBT (12 g/kg), and BLM + PFD (200 mg/kg) groups were presented (n = 5). The images in the lower panels (scale bar = 50 μm) of each staining were magnified from the inset of the photomicrographs in the upper panels (scale bar = 200 μm). (B) Quantitative analysis of Masson’s trichrome staining in the sections of mouse lungs (n = 5). (C) The pathological score of lung injury was analyzed in different groups (n = 5). ***p < 0.001, compared to the sham group; ###p < 0.001, compared to the BLM group. BLM, bleomycin; Ctrl, control; WBT, Wenfei Buqi Tongluo formula; PFD, pirfenidone.