Table 1.
Differences in hematological and apoptotic markers of patients with CLL before and during the intervention DI1 with high OC/OL-EVOO (10 patients) and low OC/OL-EVOO (10 patients). a
| Dietary intervention DI1 with High OC/OL-EVOO | ||||
|---|---|---|---|---|
| Whole blood count | Baseline a Median (min–max) |
45 days b Median (min–max) |
90 days c Median (min–max) |
p-value (adj) |
| White Blood Cells (×103/mm3) |
16,900.00 (9,200–69,600) |
12,950.00 (7,000–81,400) |
11,700.00 (7,000–57,000) |
a–b 0.040
a–c 0.000 |
| Lymphocytes (×103/mm3) |
10,800.00 (3,300–59,400) |
7,925.00 (3,100–70,000) |
7,900.00 (2,700–49,700) |
0.138 |
| Platelets (×103/mm3) |
214,000 (124,000–306,000) |
221,500 (123,000–297,000) |
201,000 (106,000–338,000) |
0.432 |
| Hematocrite (%) | 42.70 (36.40–46.00) |
41.95 (38.70–47.80) |
41.65 (35.80–47.90) |
0.740 |
| Hemoglobin (g/dl) | 14.35 (12.00–15.60) |
13.75 (12.50–16.20) |
13.90 (11.50–16) |
0.934 |
| Monocytes (×103/mm3) |
0.40 (0.10–2.10) |
0.30 (0.10–2.20) |
0.35 (0.20–1.60) |
0.442 |
| Neutrophils (×103/mm3) |
4.20 (1.70–8.00) |
4.20 (1.40–8.20) |
4.10 (1.80–6.92) |
0.159 |
| Eosinophils (×103/mm3) |
0.19 (0.06–0.54) |
0.21 (0.06–1.30) |
0.17 (0.06–0.44) |
0.459 |
| Basophils (×103/mm3) |
0.04 (0.01–0.25) |
0.04 (0.00–0.50) |
0.04 (0.01–0.23) |
0.669 |
| ccK18 (U/L) |
129.79 (47.78–389.32) |
126.70 (68.12–585.58) |
235.78 (76.51–998.00) |
a–c 0.046 |
| Apo1-Fas (U/L) |
84.49 (59.29–528.88) |
95.36 (66.01–611.81) |
93.46 (54.86–805.41) |
a–c 0.030 |
| Survivin/API4 (pg/ml) |
103.06 (86.62–133.13) |
106.86 (85.31–181.89) |
94.03 (32.00–160.00) |
b–c 0.024 |
| Dietary intervention DI1 with Low OC/OL-EVOO | ||||
| Whole blood count |
Baseline
a Median (min–max) |
45 days
b Median (min–max) |
90 days
c Median (min–max) |
p-value
(adj) |
| White Blood Cells (×103/mm3) |
22,100.00 (8,900–30,900) |
21,433.33 (8,700–26,000) |
20,400.00 (8,200–26,000) |
0.131 |
| Lymphocytes (×103/mm3) |
14,600.00 (3,300–24,400) |
15,333.33 (3,300–21,700) |
14,400.00 (2,800–21,700) |
0.248 |
| Platelets (×103/mm3) |
232,000 (140,000–289,000) |
232,333.33 (134,000–295,000) |
235,000 (125,000–321,000) |
0.607 |
| Hematocrite (%) | 42.60 (37.40–45.70) |
39.40 (12.70–47.80) |
41.65 (39.60–46.80) |
0.159 |
| Hemoglobin (g/dl) | 14.20 (12.50–15.60) |
13.40 (12.80–16.20) |
13.60 (12.70–15.60) |
0.846 |
| Monocytes (×103/mm3) |
0.60 (0.20–0.80) |
0.40 (0.20–1.00) |
0.50 (0.30–1.10) |
0.211 |
| Neutrophils (×103/mm3) |
5.20 (2.80–5.80) |
4.20 (2.30–6.30) |
4.50 (2.00–5.00) |
0.143 |
| Eosinophils (×103/mm3) |
0.17 (0.09–0.23) |
0.23 (0.10–0.29) |
0.20 (0.10–0.30) |
0.196 |
| Basophils (×103/mm3) |
0.04 (0.02–0.08) |
0.05 (0.04–0.06) |
0.04 (0.02–0.09) |
0.327 |
| ccK18 (U/L) |
117.91 (30.39–218.47) |
112.40 (55.04–149.40) |
107.71 (66.51–160.11) |
0.882 |
| Apo1-Fas (U/L) |
91.69 (69.00–121.36) |
87.62 (56.00–111.29) |
91.32 (72.00–105.00) |
1.000 |
| Survivin/API4 (pg/ml) |
103.55 (86.20–110.91) |
110.87 (102.63–159.62) |
114.13 (77.44–132.00) |
0.368 |
a
Analysis was carried using Friedman test and Dunn–Bonferroni post hoc tests.
Bold emphasize statistical significant values.