Table 2.
Differences in hematological markers of patients with CLL (N = 22) before and during the DI2 with High OC/OL-EVOO. a
| Whole blood count | 6 months before a Median (min–max) |
3 months before b Median (min–max) | Baseline c Median (min–max) | 3 months after d Median (min–max) | 6 months after e Median (min–max) | p-value (adj) |
|---|---|---|---|---|---|---|
| White Blood Cells (×103/mm3) |
13,300.00 (7,500–44,800) |
18,650.00 (6,700.00–58,300.00) |
16,900.00 (8,000.00–69,600.00) |
13,100.00 (7,000.00–57,000.00) |
11,900.00 (6,600.00–46,000.00) |
b–e 0.004 |
| Lymphocytes (×103/mm3) |
10,500.00 (3,000–43,200) |
11,650.00 (3,300.0–50,600.0) |
10,800.00 (3,300.00–59,400.00) |
8,350.00 (2,700.00–49,700.00) |
8,000.00 (2,500.00–39,400.00) |
b–e 0.000 |
| Platelets (×103/mm3) |
209,000 (124,000–277,000) |
202,000 (152,000–309,000) |
205,000 (124,000–306,000) |
201,000.00 (106,000–338,000) |
197,000.00 (101,000–321,000) |
0.944 |
| Hematocrite (%) | 42.50 (38.50–49.80) |
42.65 (36.10–49.80) |
42.70 (36.40–48.40) |
42.15 (35.80–49.50) |
41.50 (36.00–49.20) |
0.093 |
| Hemoglobin (g/dl) | 14.30 (12.80–16.30) |
14.15 (12.10–16.30) |
14.35 (12.00–15.80) |
14.10 (11.50–16.00) |
13.90 (11.70–16.50) |
0.273 |
| Monocytes (×103/mm3) |
0.30 (0.10–1.00) |
0.55 (0.10–2.00) |
0.40 (0.10–2.10) |
0.35 (0.20–1.60) |
0.30 (0.10–1.20) |
0.176 |
| Neutrophils (×103/mm3) |
3.80 (1.70–7.50) |
4.95 (2.20–8.90) |
4.20 (1.70–8.00) |
4.10 (1.80–6.92) |
3.80 (1.60–6.80) |
b–d 0.006
b–e 0.003 |
| Eosinophils (×103/mm3) |
0.19 (0.05–0.61) |
0.21 (0.06–0.64) |
0.19 (0.06–0.54) |
0.17 (0.06–0.44) |
0.2 (0.07–0.60) |
0.524 |
| Basophils (×103/mm3) |
0.03 (0.00–0.36) |
0.08 (0.00–1.26) |
0.04 (0.01–0.25) |
0.04 (0.01–0.23) |
0.02 (0.00–0.12) |
b–e 0.037 |
a
Analysis was carried using Friedman test and Dunn–Bonferroni post hoc tests.
Bold emphasize statistical significant values.