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. 2022 Jan 21;12:752934. doi: 10.3389/fphar.2021.752934

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Copyright © 2022 Tian, Welte, Mai, Liu, Ramirez and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of tetramolecular G-quadruplex. (A) Schematic view of special secondary structures of G-quadruplex. Left panel: molecular structure of a G-quartets. Right panels: Secondary structures of unimolecular, bimolecular, and tetramolecular G-quadruplexes. (B–E) Images of agarose gel electrophoresis results. Left panels: non-denatured gels; right panels: denatured gels. Orange arrows point to the monomer bands, and blue arrows point to the tetramer bands. (F) Correlation between cell binding affinity and tetramer/monomer ratio.