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. 2021 Nov 1;4(2):109–120. doi: 10.1096/fba.2021-00078

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© 2021 The Authors. FASEB BioAdvances published by The Federation of American Societies for Experimental Biology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Principal coordinate analysis (PCoA) indicated microbiome separation and increased abundance of Lactobacillus pre‐DSS. (A) Weighted PCoA indicated that there was a distinct microbial separation (p = 0.001) between the mice that lost the most weight (DSS‐sensitive: DSS‐S) and the mice that lost the least weight (DSS‐resistant: DSS‐R) after start of DSS. (B) Blautia, Faecalibaculum, and Lactobacillus separated most at pre‐DSS between the DSS resistant and DSS sensitive microbiomes (Blautia: p = 0.003; Faecalibaculum: p = 0.01; Lactobacillus: DSS‐S mean = 3.53%, DSS‐R mean = 9.32%, p = 0.04) [Colour figure can be viewed at wileyonlinelibrary.com]