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. 2022 Jan 21;13:809433. doi: 10.3389/fnagi.2021.809433

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Copyright © 2022 Cai, Chai, Fu, Wang, Zhang, Zhang, Zhu, Miao and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sal ameliorates AD by suppressing NLRP3-mediated pyroptosis. The primary mechanism is described below: (1) Sal directly reducing the accumulation of Aβ, thus inhibited pyroptosis by blocking the NLRP3 inflammasome activation, mainly through inhibiting NLRP3/caspase-1 signaling pathways; (2) Sal indirectly suppressed pyroptosis through inhibiting TLR4, the mechanism may via TLR4/NF-κB/NLRP3 signaling pathways. These results exhibited that inhibiting pyroptosis through treatment by Sal could be a new approach in the therapeutic treatment of AD.