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. 2022 Jan 21;13:809433. doi: 10.3389/fnagi.2021.809433

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Copyright © 2022 Cai, Chai, Fu, Wang, Zhang, Zhang, Zhu, Miao and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sal suppressed pyroptosis in Aβ1-42 and D-gal/AlCl₃-induced AD mice via NLRP3/Caspase-1 or TLR4/NF-κB/NLRP3/Caspase-1 signaling pathway. Immunochemical staining of NLRP3 (A), cleaved caspase-1 (B) in the CA1, CA3, and DG regions of the hippocampus of AD mice brains, and the IHC staining results are shown by arrows; scale bar = 50 μm, Original magnification: x200. Quantitative analyses of the NLRP3, cleaved caspase-1 positive area in the hippocampus by Image J. Values are expressed as mean ± SEM (n = 3). ^##P < 0.01, ^###P < 0.001, vs. control group, ^*P < 0.05, ^**P < 0.01, ^***P < 0.01 vs. Aβ1-42 and D-gal/AlCl₃ group.