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. Author manuscript; available in PMC: 2022 Feb 4.
Published in final edited form as: Nature. 2021 Apr 29;595(7865):114–119. doi: 10.1038/s41586-021-03569-1

Extended Data Fig. 3 |. Effect of sex on cellular composition and host receptor expression.

Extended Data Fig. 3 |

a, b, Cell fractions in female and male individuals for control (a; n = 7 donors) and COVID-19 lungs (b; n = 19 donors examined over 20 experiments). Middle line, median; box edges, 25th and 75th percentiles; whiskers, most extreme points that do not exceed ±1.5 × IQR. Wilcoxon rank-sum test. c, d, Log-normalized and scaled expression (see Methods) of selected receptors or putative receptors and proteases or putative proteases involved in SARS-CoV-2 entry in different cell types in control samples from female and male donors. Dot size indicates fraction of cells and colour indicates expression level. e, f, As in c, d for from COVID-19 lungs.