Table 2.

Melanoma.

Year, Ref.	Findings
2006 285	Silymarin proposed for chemoprevention of melanoma.
2007 286	Silymarin increased proapoptotic effects of anti-Fas agonistic antibody CH11 in melanoma cells.
2013 287	Silymarin for prevention for melanoma invasion.
2013 288 X	Silymarin decreased the growth of melanoma xenografts and locked MEK1/2-ERK1/2-RSK signaling that led to a reduction of NF-kB activator protein1 and STAT3, which resulted in cell cycle arrest and inhibited tumor growth in vitro and in vivo
2015 289 X	Silymarin targeted cell cycle regulators, angiogenesis, and induced apoptosis in vitro and in vivo.
2016 290	Silymarin as a modulator of the wnt/β catenin pathway.