Table 6.

Pancreas.

Year, Ref.	Findings
2011 320	Silibinin induced cell cycle arrest and apoptosis in certain pancreatic cancer cell lines.
2015 321	The combination of an HDAC inhibitor and silibinin had additive effects on growth inhibition and apoptosis of pancreatic cancer cells.
2015 322 X	In an orthotopic model of pancreatic cancer, silibinin reduced glycolytic activity of cancer cells, proliferation, and cachexia.
2013 323 X	Dose-dependent cell growth inhibition was produced by silibinin concentrations between 25 and 100 μM. In xenograft in nude mice, tumor weight was significantly decreased by dietary silibinin.
2018 324	SW1990 pancreatic cancer cells showed G1 arrest with decreased cyclins and CDKs and apoptosis with silibinin.