Fig. 5.

Mean injection intervals across the study (cycles 1–9) and in the first 4 cycles. Statistical differences (p values) between brands were estimated using the multivariate model (brackets). Botulinum toxin (BoNT-A) doses remained relatively stable between cycles 1 and 4; mean doses were 814–859 U for abobotulinumtoxinA (Abo), 239–254 U for onabotulinumtoxinA (Ona) and 264–275 U for incobotulinumtoxinA (Inco). Factors explored in the regression model were: toxin, age, sex, previously treated for upper limb spasticity (ULS) with BoNT, time from event onset to Cycle 1, distribution of spasticity, dominance of affected limb, indication of lower limb spasticity, duration of BoNT-A prior to study, systemic antispastic medications (and ratio), injection guidance technique, mean indexed dose, any physiotherapy during the study and number of therapy visits. SD: standard deviation.