Table II.
Estimated mean magnetic resonance imaging outcomes
| Outcome measures | Group | Adjusted mean changes at 3-month follow-up Mean (95% CI) | Difference between groups at 3-month follow-up Mean (95% CI) |
|---|---|---|---|
| T2 lesiona | Intervention | -0.22 (-1.28 to 0.84) | 0.15 (-0.51 to0.80) |
| Control | -0.36 (-0.95 to 0.22) | ||
| T2 lesionb | Intervention | 1.35 (-1.51 to 4.22) | -0.13 (-1.90 to1.64) |
| Control | 1.48 (-0.10 to 3.07) | ||
| Gadolinium-enhancing lesiona | Intervention | -0.07 (-0.31 to 0.16) | -0.12 (-0.24 to0.00) |
| Control | 0.05 (-0.07 to 0.17) | ||
| Gadolinium-enhancing lesionb | Intervention | -0.25 (-4.72 to 4.21) | -2.35 (-4.66 to-0.04) |
| Control | 2.10 (-0.21 to 4.40) | ||
| Cortical lesiona | Intervention | 0.05 (-0.04 to 0.13) | 0.03 (-0.02 to0.09) |
| Control | 0.01 (-0.06 to 0.08) | ||
| Cortical lesionb | Intervention | 1.30 (-0.68 to 3.28) | 0.48 (-0.74 to1.70) |
| Control | 0.82 (-0.28 to 1.91) | ||
| Whole brainc | Intervention | -0.06 (-0.21 to 0.09) | -0.07 (-0.16 to0.02) |
| Control | 0.01 (-0.07 to 0.09) | ||
| Grey matterc | Intervention | -0.03 (-0.19 to 0.13) | -0.01 (-0.12 to0.11) |
| Control | -0.02 (-0.14 to 0.10) | ||
| Lateral ventriclec | Intervention | -0.03 (-2.57 to 2.51) | -0.57 (-2.14 to1.00) |
| Control | 0.53 (-0.87to 1.94) | ||
| Thalamusc | Intervention | -0.05 (-0.96 to 0.86) | 0.44 (-0.12 to1.00) |
| Control | -0.48 (-0.99 to 0.02) | ||
| Basal ganglia totalc | Intervention | -0.10 (-0.28 to 0.08) | -0.11 (-0.24 to0.02) |
| Control | 0.01 (-0.14 to 0.15) | ||
| Nucleus accumbensc | Intervention | -0.64 (-2.29 to 1.01) | -0.52 (-1.54 to0.50) |
| Control | -0.12 (-1.03 to 0.80) | ||
| Pallidumc | Intervention | -0.10 (-1.16 to 0.95) | 0.26 (-0.41 to0.92) |
| Control | -0.36 (-1.34 to 0.62) | ||
| Putamenc | Intervention | -0.41 (-1.04 to 0.23) | -0.59 (-0.99 to-0.20) |
| Control | 0.18 (-0.17 to 0.54) | ||
| Caudatec | Intervention | -0.16 (-1.17 to 0.85) | -0.12 (-0.74 to0.50) |
| Control | -0.04 (-0.60 to 0.51) | ||
| Limbic lobe totalc | Intervention | -0.23 (-0.73 to 0.27) | -0.20 (-0.51 to0.11) |
| Control | -0.03 (-0.30 to 0.25) | ||
| Anterior cingulate gyrusc | Intervention | -0.35 (-0.94 to 0.25) | -0.20 (-0.57 to0.17) |
| Control | -0.15 (-0.48 to 0.19) | ||
| Middle cingulate gyrusc | Intervention | -0.50 (-1.37 to 0.36) | -0.41 (-0.95 to0.12) |
| Control | -0.09 (-0.57 to 0.39) | ||
| Posterior cingulate gyrusc | Intervention | -0.39 (-1.28 to 0.50) | -0.63 (-1.18 to-0.08) |
| Control | 0.24 (-0.25 to 0.73) | ||
| Medial temporal lobe totalc | Intervention | 0.05 (-0.60 to 0.70) | -0.23 (-0.59 to0.13) |
| Control | 0.28 (-0.36 to 0.91) | ||
| Amygdalac | Intervention | 0.18 (-0.67 to 1.03) | 0.43 (-0.09 to0.96) |
| Control | -0.25 (-0.72 to 0.22) | ||
| Hippocampusc | Intervention | -0.05 (-0.74 to 0.64) | -0.09 (-0.52 to0.34) |
| Control | 0.04 (-0.34 to 0.42) | ||
| Parahippocampusc | Intervention | 0.33 (-0.03 to 0.69) | 0.34 (0.11to 0.56) |
| Control | -0.01 (-0.21 to 0.19) |
a
Volume change, ml
b
count change
c
volume change, %.
95% CI: 95% confidence interval.