Figure 1:

Average Monthly Subjective Opioid Withdrawal Scale (SOWS) Score per Patient Stratified by CYP3A4 Phenotype. This heat map depicts the average monthly SOWS score per month over an 18-month span of patient encounters. Each column represents the month of patient encounter, each row depicts an individual patient, and the color of the rectangle depicts the monthly average SOWS score. The patient rows are stratified by CYP3A4 phenotype, with white lines demarcating the IM, EM, and UM groupings. The color bar on the right indicates the relationship between the color of the rectangle and the SOWS score. The first six months (January 2016 – June 2016) comprise the SOC period in which patients were limited to a SBN maximum daily dose of 24 mg. The remaining 12 months (July 2016 – June 2017) comprise the PGx period in which patients could receive SBN doses exceeding 24 mg/day. The white vertical line after June 2016 demarcates the end of the SOC period. Note that within the SOC period, there is a tendency towards higher monthly average SOWS scores among the UMs compared to the EMs and IMs. Also note that during the PGx period, there is an overall observable reduction in monthly average SOWs scores compared to the SOC period.