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. Author manuscript; available in PMC: 2022 Feb 4.
Published in final edited form as: J Natl Med Assoc. 2019 Oct 31;111(6):674–681. doi: 10.1016/j.jnma.2019.09.006

Figure 3:

Figure 3:

Total Number of Unauthorized Substances Found in Toxicology Screens per Month. This heat map depicts the total number of unauthorized substances found in toxicology screens per month over an 18-month span of patient encounters. Each column represents the month of patient encounter, each row depicts an individual patient, and the color of the rectangle depicts the total number of unauthorized substances per month. The patient rows are stratified by CYP3A4 phenotype, with IM on top, EM in the middle, and UM on the bottom. The color bar on the right indicates the number of unauthorized substances found in toxicology screens per month. The first six months (January 2016 – June 2016) comprise the SOC period in which patients were limited to a SBN maximum daily dose of 24 mg. The remaining 12 months (July 2016 – June 2017) comprise the PGx period in which patients could receive SBN doses exceeding 24 mg/day. The white vertical line after June 2016 demarcates the end of the SOC period. Note that within the SOC period, there is a tendency towards higher total numbers of unauthorized substances found in toxicology screens per month with UMs compared to the EMs and IMs.