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. Author manuscript; available in PMC: 2022 Feb 4.
Published in final edited form as: Nat Biotechnol. 2018 Apr 5;36(4):311–313. doi: 10.1038/nbt.4118

Figure 1.

Figure 1

Schematic of the approach used by da Cruz et al.3. (a) In wet AMD, choroidal blood vessels penetrate through the RPE, leaking fluid in the subretinal space between the RPE (light brown) and the retina. (b) An hESC-RPE monolayer on a plastic substrate (green) is delivered to the area of vessel leakage and detachment of the RPE and retina. (c) The expected outcome is that once the retina is flattened on top of the patch, patient photoreceptors (orange) recover function through interaction with transplanted RPE cells, and cytokine cues from the RPE cells cause choroidal vessels to stop proliferating and leaking.