Changes in testis volumes (A) and serum testosterone levels (B) in monkeys during the study. The vertical red and blue dashed lines represent the times of the two doses of irradiation and of transplantation, respectively. The average values for the 3 monkeys receiving GnRH-ant treatment (filled cicle) (n=3) or sham injections (open circle) (n=3) before transplantation are plotted. The grey shaded area represents the duration of the GnRH-ant treatment. For statistical analysis the axis was divided into three time segments, after initial irradiation, after the second irradiation during GnRH-ant treatment, and after transplantation, during which there were 15, 6 and 13 comparisons, respectively. The only statistical difference between the two treatments groups (marked with asterisks) was decreased serum testosterone during the GnRH-ant treatment.