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. 2022 Feb 4;22:139. doi: 10.1186/s12885-021-09136-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Collagens are significantly mutated in stomach adenocarcinoma in the TCGA dataset. A. Distribution of alteration frequencies for collagen genes (orange) compared to all other genes (blue) in the TCGA STAD cohort. P-value determined by Wilcoxon rank test comparing the distribution of collagen genes relative to all other genes. B. Alteration frequencies for each collagen gene in all TCGA STAD cases. C. and in MSS, MSIH, and MSIL STAD cases. D. Kolmogorov-Smirnov moderated tests suggest that collagen genes as a group are significantly mutated compared to gene sets of similar size and length in the whole TCGA STAD cohort and in both MSS and MSIH tumors