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. 2022 Feb 4;22:139. doi: 10.1186/s12885-021-09136-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Tumors with collagen mutations have distinct expression of cancer hallmarks and tumor environments. A. Representative enrichment plots from pre-rank GSEA suggest upregulation of E2F regulated transcripts and down-regulation of the expression of the matrisome in tumors with collagen mutations. TCGA stomach tumors were classified by collagen mutation status and pre-ranked GSEA revealed associations with the indicated gene set. B. Heat map of normalized enrichment scores of the cancer hallmark, immune cell, and NABA ECM gene sets. Red indicates higher expression in mutant tumors and blue indicates higher expression in wild-type tumors. Nonsignificant and modest enrichment scores between − 1.5 and 1.5 are in white. In the full STAD TCGA cohort, tumors with any collagen mutation or with only mutations in COL7A1 or COL11A1 showed similar patterns. C. Heatmap of gene sets in MSS only tumors. D. Heatmaps of gene sets in MSIH only tumors reveal a more diverse pattern of enrichment. All heatmaps generated in Morpheus [38]