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. 2022 Feb 4;17:23. doi: 10.1186/s13014-021-01960-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Pediatric low-grade glioma case study. treatment planning considerations for high priority sparing in the left optic nerve to preserve vision/function and reduce risk of toxicity in the ocular system (a). FRoG-assisted treatment design is displayed with five potential plans (Tx.#1-.#5). Beam angle arrangement for the various plans using 2 or 3 beams, clinical RBE (RBE_1.1), variable RBE applying the McNamara et al. model (vRBE_MCN) and LET_d (b). RBE-weighted dose volume histogram (D_RBEVH) applying vRBE_MCN and LETd volume histogram (LETVH) in the contralateral optic nerve (L) for the five plans (I-V) are displayed (c)

Fig. 4 — Pediatric low-grade glioma case study. treatment planning considerations for high priority sparing in the left optic nerve to preserve vision/function and reduce risk of toxicity in the ocular system (a). FRoG-assisted treatment design is displayed with five potential plans (Tx.#1-.#5). Beam angle arrangement for the various plans using 2 or 3 beams, clinical RBE (RBE_1.1), variable RBE applying the McNamara et al. model (vRBE_MCN) and LET_d (b). RBE-weighted dose volume histogram (D_RBEVH) applying vRBE_MCN and LETd volume histogram (LETVH) in the contralateral optic nerve (L) for the five plans (I-V) are displayed (c)