Table 2.

Categories of pathways predicted to involve the candidate drugs

Category	Pathway name	E-score*	P value
Mitotic cell cycle	Mitotic nuclear envelope disassembly	− 0.73	5.63E−06
	Mitotic cell cycle	− 0.70	1.61E−05
	G1/S transition of mitotic cell cycle	− 0.59	5.60 E−04
	Mitotic metaphase plate congression	− 0.52	3.03 E−03
	Mitotic sister chromatid segregation	− 0.51	4.24 E−03
	Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	− 0.51	4.33 E−03
	Negative regulation of mitotic cell cycle	0.50	4.76 E−03
	Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	− 0.47	1.04 E−02
	Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	− 0.45	1.57 E−02
	Mitotic cell cycle arrest	0.44	1.97 E−02
ER stress	Endoplasmic reticulum unfolded protein response	0.70	1.49 E−05
	Response to endoplasmic reticulum stress	0.66	6.22 E−05
	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	0.56	1.07 E−03
Glucose transport	Regulation of glucose transport	− 0.70	1.79 E−05
	Glucose transport	− 0.51	4.59 E−03
	Negative regulation of glucose import	0.49	7.22 E−03
	Cellular response to glucose starvation	0.46	1.37 E−02
Autophagy	Positive regulation of autophagy	0.54	2.01 E−03
	Autophagy	0.52	3.08 E−03
	Regulation of autophagy	0.47	1.15 E−02

^* Escore: Enrichment score from − 1 to + 1, refer to down/up-regulation