Table 3.
The ontology of predicted target genes
| Predicted targets | Norcyclobenzaprine | |||
|---|---|---|---|---|
| GO biological process complete | Over/under | Fold enrichment | FDR | |
|
PARP1 PARP2 ORM2 RBP1 SETD7 ESRRG PGR ESR1 NCOA2 RARB |
Positive regulation of RNA biosynthetic process (GO:1902680) | + | 7.78 | 3.68 E−03 |
| Positive regulation of transcription DNA-templated (GO:0045893) | + | 7.78 | 4.39 E−03 | |
| Positive regulation of RNA metabolic process (GO:0051254) | + | 7.15 | 4.66 E−03 | |
| Positive regulation of macromolecule biosynthetic process (GO:0010557) | + | 6.8 | 4.69 E−03 | |
| Transcription initiation from RNA polymerase II promoter (GO:0006367) | + | 41.69 | 4.84 E−03 | |
| Positive regulation of macromolecule metabolic process (GO:0010604) | + | 4.5 | 4.92 E−03 | |
| Positive regulation of transcription by RNA polymerase II (GO:0045944) | + | 9.15 | 4.93 E−03 | |
| Response to steroid hormone (GO:0048545) | + | 27.79 | 4.94 E−03 | |
| Intracellular receptor signaling pathway (GO:0030522) | + | 32 | 4.97 E−03 | |
| Positive regulation of biosynthetic process (GO:0009891) | + | 6.32 | 5.03 E−03 | |
| Epithelial cell development (GO:0002064) | + | 31.37 | 5.11 E−03 | |
| transcription by RNA polymerase II (GO:0006366) | + | 20.74 | 5.11 E−03 | |
| positive regulation of cellular biosynthetic process (GO:0031328) | + | 6.44 | 5.14 E−03 | |
| DNA-templated transcription initiation (GO:0006352) | + | 32.5 | 5.24 E−03 | |
| DNA ADP-ribosylation (GO:0030592) | + | > 100 | 5.27 E−03 | |
| Peptidyl-serine ADP-ribosylation (GO:0018312) | + | > 100 | 5.44 E−03 | |
| Positive regulation of nucleic acid-templated transcription (GO:1903508) | + | 7.78 | 5.49 E−03 | |
| Response to hormone (GO:0009725) | + | 11.61 | 5.74 E−03 | |
| Positive regulation of metabolic process (GO:0009893) | + | 4.15 | 5.76 E−03 | |
| Positive regulation of nucleobase-containing compound metabolic process (GO:0045935) | + | 6.53 | 5.93 E−03 | |
| Hormone-mediated signaling pathway (GO:0009755) | + | 48.37 | 6.34 E−03 | |
| Cellular response to hormone stimulus (GO:0032870) | + | 17.97 | 6.92 E−03 | |
| Mammary gland branching involved in pregnancy (GO:0060745) | + | > 100 | 7.72 E−03 | |
| RNA biosynthetic process (GO:0032774) | + | 14.59 | 7.95 E−03 | |
| Retinoic acid biosynthetic process (GO:0002138) | + | > 100 | 8.02 E−03 | |
| Steroid hormone mediated signaling pathway (GO:0043401) | + | 66.01 | 8.16 E−03 | |
| Nucleic acid-templated transcription (GO:0097659) | + | 14.92 | 8.33 E−03 | |
| Transcription, DNA-templated (GO:0006351) | + | 14.95 | 8.61 E−03 | |
| Diterpenoid biosynthetic process (GO:0016102) | + | > 100 | 8.69 E−03 | |
| Positive regulation of nitrogen compound metabolic process (GO:0051173) | + | 4.57 | 8.70 E−03 | |
| Protein poly-ADP-ribosylation (GO:0070212) | + | > 100 | 8.98 E−03 | |
| Vitamin A metabolic process (GO:0006776) | + | > 100 | 9.95 E−03 | |
| Predicted targets | Protriptyline | |||
|---|---|---|---|---|
| GO biological process complete | Over/under | Fold enrichment | FDR | |
|
RBP1 PGR NCOA2 PARP2 PARP1 RXRA RARB CHKA RARG ORM2 |
Cellular response to hormone stimulus (GO:0032870) | + | 17.97 | 3.46 E−03 |
| Retinoic acid receptor signaling pathway (GO:0048384) | + | > 100 | 4.74 E−03 | |
| Hormone-mediated signaling pathway (GO:0009755) | + | 48.37 | 6.34 E−03 | |
| Transcription by RNA polymerase II (GO:0006366) | + | 20.74 | 8.18 E−03 | |
| Positive regulation of transcription by RNA polymerase II (GO:0045944) | + | 9.15 | 8.21 E−03 | |
| DNA ADP-ribosylation (GO:0030592) | + | > 100 | 8.29 E−03 | |
| Transcription initiation from RNA polymerase II promoter (GO:0006367) | + | 41.69 | 8.47 E−03 | |
| Epithelial cell development (GO:0002064) | + | 31.37 | 8.51 E−03 | |
| Intracellular receptor signaling pathway (GO:0030522) | + | 32 | 8.59 E−03 | |
| DNA-templated transcription, initiation (GO:0006352) | + | 32.5 | 8.91 E−03 | |
| Peptidyl-serine ADP-ribosylation (GO:0018312) | + | > 100 | 9.66 E−03 | |