TABLE 2.
The role of cannabinoid receptor ligands in regulating tumor cells and bone diseases in vitro and in vivo.
| Ligand | Receptor | Bone tumor | |||
|---|---|---|---|---|---|
| Tm.Growth | Osteolysis | Pain | |||
| Agonists | AEA | CB1/CB2/GPR55/TRPV1 | ↓↓ | - | ↓ |
| 2-AG | CB1/CB2/GPR55 | ↓ | ↓ | - | |
| Δ9-THC | CB1/CB2 | ↓↓↑↑ | - | ↓ | |
| CP55,940 | CB1/CB2 | ↓ | - | ||
| WIN55,212 | CB1 | ↓↓ | - | ||
| HU308 | CB2 | ↑↓ | ↑ | - | |
| JWH133 | CB2 | ↑↓↓ | ↓↓↑ | ||
| JWH139 | CB2 | ↓ | - | ||
| JWH015 | CB2 | ↓↓ | ↓ | ↓ | |
| AM1241 | CB2 | ↓ | ↓ | ||
| Lysophosphatidyl inositol | GPR55 | - | - | - | |
| O-1602 | GPR55 | - | - | ||
| Antagonists | AM630 | CB2>CB1/GPR55 | - | ↓ | |
| SR144528 | CB2>CB1 | - | - | ||
| AM251 | CB1>CB2/GPR55 | - | - | ||
| SR141716A | CB1>CB2 | - | - | ||
| Cannabidiol | GPR55 | ↓↓ | - | ↓ | |
Abbreviations: CB1, cannabinoid type 1 receptor; CB2, cannabinoid type 2 receptor; GPR55, G protein-coupled receptor 55; TRPV1, transient receptor potential vanilloid type 1. Tm., tumor cell. ↑, increase; ↓, decrease; –, non tested. Black and red arrows denote in vitro and in vivo data, respectively.