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. Author manuscript; available in PMC: 2022 Apr 26.
Published in final edited form as: Sci Signal. 2021 Oct 26;14(706):eabe3410. doi: 10.1126/scisignal.abe3410

Fig. 6. A schematic model for Lyn in NLRP3 inflammasome activation.

Fig. 6.

When macrophages from WT mice are primed with LPS, and stimulated with soluble stimuli such as ATP, Lyn is activated, and then phosphorylates NLRP3 at Tyr 918 which is a prerequisite for NLRP3 ubiquitination and subsequent degradation in the proteasome. In the absence of Lyn, NLRP3 tyrosine phosphorylation and subsequent ubiquitination is abrogated, which results in heightened NLRP3 protein expression, and activation.