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Inhibition of recombinant PfPRMT1 activity and P. falciparum 3D7-luc growth by small molecule inhibitors.
| Compounds | Structures | IC50s for PRMT1 activity (μM) | IC50s for 3D7 growth (μM) |
|---|---|---|---|
| Sinefungin |
|
0.84 ± 0.15 | 2.71 ± 0.04 |
| 5-Deoxy-5-methylthioadenosine (MTA) |
|
>360 | >100 |
| Eosin Y (AMI-5) |
|
11.62 ± 0.08 | 14.79 ± 1.01 |
| Chaetocin |
|
>120 | 14.00 ± 1.56 |
| Adenosine-2’,3’-dialdehyde (AdoX) |
|
Not determined | 8.72 ± 0.73 |
