Table 1.
Basic biometric data and food consumption of rats exposed to high-fat-fructose diet during a 13 weeks and impact of 5-week-lasted treatment with the compound SMe1EC2 (S) and rutin (R)
| Parameter | C | HFFD | HFFD-S | HFFD-R |
|---|---|---|---|---|
| Body weight | ||||
| At onset, rats 4 w old (g) | 49.92±5.81 | 48.43±4.30 | 44.34±2.63 | 41.50±5.44 |
| At the end, rats 21 w old (g) | 366.42±10.60 | 381.71±7.32 | 386.02±4.82 | 387.01±8.40 |
| Body weight gain (g) | 316.50 ±10.61 | 333.30±7.25 | 341.70±4.76 | 345.50±8.43 |
| Body weight gain (%) | 634.27±21.25 | 688.64±14.98 | 771.33±10.75***,# | 832.53±20.31***,### |
| Food consumption | ||||
| Pellets intake (g/rat/day) | 20.90±0.95 | 21.72±0.81 | 22.20±0.80 | 21.90±0.81 |
| Energy intake (kJ/rat/day) | 299.50±13.81 | 352.38±12.68* | 360.04±12.37* | 356.49±12.20* |
| Liver | ||||
| Liver weight (g) | 9.66±0.51 | 14.03±0.46*** | 14.29±0.39*** | 15.05±0.64*** |
| Liver weight / Body weight (%) | 2.63±0.11 | 3.68±0.13*** | 3.70±0.08*** | 3.88±0.13*** |
| Heart | ||||
| Heart weight (g) | 1.14±0.01 | 1.23±0.02 | 1.19±0.02 | 1.15±0.03 |
| Heart weight / Body weight (%) | 0.31±0.01 | 0.32±0.01 | 0.31±0.01 | 0.30±0.01 |
| Kidney | ||||
| Kidneys weight (g) | 2.15±0.06 | 1.95±0.04* | 1.94±0.03* | 1.95±0.05* |
| Kidneys weight / Body weight (%) | 0.59±0.01 | 0.51±0.02*** | 0.50±0.01*** | 0.50±0.01*** |
All values are expressed as mean ± SEM. Number of rats per group, n = 10. Experimental group abbreviations explained in Fig. 1., w - week, statistical difference vs. control group
*
p ≤ 0.05,
***
p ≤ 0.001, statistical difference vs. HFFD group
#
p ≤ 0.05,
###
p ≤ 0.001. Statistical significance was determined by ANOVA, Bonferroni comparison test.