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. 2021 Oct 30;70(6):851–863. doi: 10.33549/physiolres.934670

Table 2.

Functional parameters of isolated rat hearts measured at the end of stabilization (STAB) and at the end of reperfusion (REP) followed after ischemia

Parameter C HFFD HFFD-S HFFD-R
Heart rate (HR) (beats/min) STAB 285.45±26.12 279.77±15.42 302.18±27.7 289.44±12.04
REP 254.40±21.49 272.74±12.20 286.08±9.13 250.45±22.67
Left ventricular systolic pressure (LVSP) (kPa) STAB 9.85±1.41 10.32±1.59 12.53±1.00 10.82±1.43
REP 11.65±0.31 11.74±1.02 12.65± 1.33 10.67±2.54
End diastolic left ventricular pressure (EDLVP) (kPa) STAB 0.62±0.30 0.33±0.11 0.52±0.21 1.28±0.27#
REP 0.91±0.30 0.38±0.20 0.22±0.12 1.12±0.67
−dP/dt max (kPa/s) STAB 168.33±29.33 189.71±33.45 227.56±18.66 216.30±39.43
REP 124.15±57.21 217.92±20.94 186.85±27.26 160.69±37.54
+dP/dt max (kPa/s) STAB 249.74±46.69 271.83±47.28 316.96±27.05 267.84±43.93
REP 178.63±78.94 313.16±30.66 271.99±37.4 237.16±52.02
−dP/dt max / +dP/dt max STAB 0.68±0.02 0.68±0.03 0.72±0.02 0.77±0.11
REP 0.65±0.06 0.72±0.01 0.68±0.02 0.64±0.04
Heart Product (HP) (kPa x beats/min) STAB 2603.07±399.26 2947.42±538.78 3821.26±459.65 3214.54±507.63
REP 2968.86±307.59 3176.44±277.93 3614.64±222.88 2512.15±579.64
Coronary flow (CF) (ml/min) STAB 9.51±1.22 10.22±1.25 12.84±1.78 11.22±0.65
REP 9.34±0.57 11.16±0.72 14.43±1.89 * 12.00±1.28

All values are means ± SEM. Number of rats per group, n = 10. Experimental group abbreviations explained in Fig. 1, significant difference in EDLVP at the end of stabilization

#

p < 0.05 HFFD vs. HFFD-R, in CF at reperfusion

*

p < 0.05 HFFD-S vs. C, ANOVA, Bonferroni comparison test.