Table 2.
Parameter | C | HFFD | HFFD-S | HFFD-R | |
---|---|---|---|---|---|
Heart rate (HR) (beats/min) | STAB | 285.45±26.12 | 279.77±15.42 | 302.18±27.7 | 289.44±12.04 |
REP | 254.40±21.49 | 272.74±12.20 | 286.08±9.13 | 250.45±22.67 | |
Left ventricular systolic pressure (LVSP) (kPa) | STAB | 9.85±1.41 | 10.32±1.59 | 12.53±1.00 | 10.82±1.43 |
REP | 11.65±0.31 | 11.74±1.02 | 12.65± 1.33 | 10.67±2.54 | |
End diastolic left ventricular pressure (EDLVP) (kPa) | STAB | 0.62±0.30 | 0.33±0.11 | 0.52±0.21 | 1.28±0.27# |
REP | 0.91±0.30 | 0.38±0.20 | 0.22±0.12 | 1.12±0.67 | |
−dP/dt max (kPa/s) | STAB | 168.33±29.33 | 189.71±33.45 | 227.56±18.66 | 216.30±39.43 |
REP | 124.15±57.21 | 217.92±20.94 | 186.85±27.26 | 160.69±37.54 | |
+dP/dt max (kPa/s) | STAB | 249.74±46.69 | 271.83±47.28 | 316.96±27.05 | 267.84±43.93 |
REP | 178.63±78.94 | 313.16±30.66 | 271.99±37.4 | 237.16±52.02 | |
−dP/dt max / +dP/dt max | STAB | 0.68±0.02 | 0.68±0.03 | 0.72±0.02 | 0.77±0.11 |
REP | 0.65±0.06 | 0.72±0.01 | 0.68±0.02 | 0.64±0.04 | |
Heart Product (HP) (kPa x beats/min) | STAB | 2603.07±399.26 | 2947.42±538.78 | 3821.26±459.65 | 3214.54±507.63 |
REP | 2968.86±307.59 | 3176.44±277.93 | 3614.64±222.88 | 2512.15±579.64 | |
Coronary flow (CF) (ml/min) | STAB | 9.51±1.22 | 10.22±1.25 | 12.84±1.78 | 11.22±0.65 |
REP | 9.34±0.57 | 11.16±0.72 | 14.43±1.89 * | 12.00±1.28 |
All values are means ± SEM. Number of rats per group, n = 10. Experimental group abbreviations explained in Fig. 1, significant difference in EDLVP at the end of stabilization
p < 0.05 HFFD vs. HFFD-R, in CF at reperfusion
p < 0.05 HFFD-S vs. C, ANOVA, Bonferroni comparison test.