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. 2021 Oct 30;70(6):821–829. doi: 10.33549/physiolres.934755

Fig. 3.

Fig. 3

Functions, features and phenotypes of HSC in normal and liver fibrosis, and activated HSC clearance approaches. Quiescent HSC in normal liver plays a vital role during liver development, regeneration, and vitamin A storage. Activated HSC is related with liver fibrosis. There are three activated HSCs clearance approaches: apoptosis, senescence, and reversion.