Fig. 5.

PI3K/AKT signaling pathway agonist inhibited miR-18a-induced interference on PDGF-BB-related proliferation, apoptosis, migration and phenotypic transformation of ASMCs. A) MTT assay examination on the changes in cell proliferation ability of each treatment group, B) Flow cytometry outcome on the apoptosis of each treatment group, C) Transwell detection of the changes in cell migration ability of each treatment group, D: Western blot results on the expression levels of SM-22α, α-SM-actin, and calponin in cells of each treatment group, D) Quantitative analysis of gray values of SM-22α, α-SM-actin, and calponin bands, respectively. **P<0.01, ***P<0.001 vs. PDGF-BB group. ^##P<0.01, ^###P<0.001 vs. PDGF-BB+mi-miR-18a group.