Table 1.

Infusion protocols for each modality of anticoagulation

Anticoagulation Regimen	Initial Bolus (U/kg)	Maximum Bolus (U)	Starting Infusion Rate	Goal aPTT (s)	Goal anti-Xa (IU/ml)	Maximum Infusion Rate
Regional citrate ACD-A	None	N/A	22.4 mmol/hr (200 ml/h)	N/A	N/A	33.6 mmol/h (300 ml/h)
Prefilter heparin	None	N/A	200 U/h	None	None	600 U/h
Minimally intensive heparin	None	N/A	12 U/kg per h	39–54	0.3–0.5	None
Low-intensity heparin	60	4000	12 U/kg per h	39–69	0.3–0.5	None
High-intensity heparin	80	None	18 U/kg per h	39–69	0.3–0.7	None

ACD-A contains 3% citrate (112 mmol/L, dextrose-sodium-citrate-citric acid 2.45–2.2 g –800 mg/100 ml solution). Heparin formulation was 25,000 units (U)/500 ml 5% dextrose solution. Dialysate calcium concentration was 1.0–2.25 mEq/L with regional citrate and 2.5–3.0 mEq/L with heparin-based anticoagulation. aPTT, activated partial thromboplastin time; ACD-A, anticoagulant dextrose citrate solution-A; N/A, not applicable.