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. 2022 Jan 21;12:794997. doi: 10.3389/fphar.2021.794997

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Copyright © 2022 Estornut, Milara, Bayarri, Belhadj and Cortijo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified diagram of the principal molecular mechanisms of the NOX inhibitors Diphenyleneiodonium (DPI), VAS2870, GKT137831 and GKT136901 (GKTs), Apocynin (APO) and Metformin (MET). αSMA: alpha smooth muscle actin; IL-1β: interleuquina 1beta; IL-6: interleuquina 6; iNOS: inducible nitrogen oxide synthase; NFκβ: nuclear factor kappa beta; NOX1,2,4: NADPH oxidases; ROS/RNS: reactive oxygen species/reactive nitrogen species; TGF-β1: transforming growth factor beta 1; TNFα: tumoral necrosis factor alpha Created with Biorender.com.