Table 3.

Neurologic side effects of calcineurin inhibitors

Severity	Central Toxicity	Peripheral Toxicity
Minor	Insomnia, visual disturbances, headache, and mood changes	Paraesthesias, peripheral neuropathy, and myopathy
Major	PRES, akinetic mutism, toxic encephalopathy, and convulsions	Axonal and demyelinating neuropathy, Guillain–Barré syndrome

PRES, posterior reversible encephalopathy syndrome.