Table 2.

KidneyIntelX thresholds for the composite kidney end point with sensitivity, specificity, PPV and NPV for T2D and APOL1-HR populations in high- and low-risk strata

Threshold	Risk Cutoff	Sensitivity	Specificity	PPV	NPV
T2D KidneyIntelX
Bottom 50%	0.192	0.82	0.59	0.38	0.92
Top 20%	0.444	0.50	0.89	0.58	0.86
Top 15%	0.555	0.40	0.93	0.62	0.84
Top 10%	0.707	0.29	0.96	0.68	0.82
T2D clinical model
Bottom 50%	0.148	0.68	0.55	0.31	0.85
Top 20%	0.240	0.38	0.85	0.43	0.82
Top 15%	0.278	0.30	0.89	0.46	0.81
Top 10%	0.338	0.23	0.94	0.54	0.80
APOL1-HR KidneyIntelX
Bottom 50%	0.209	0.88	0.58	0.32	0.96
Top 20%	0.438	0.60	0.89	0.56	0.91
Top 15%	0.489	0.52	0.93	0.62	0.90
Top 10%	0.546	0.36	0.96	0.66	0.87
APOL1-HR clinical model
Bottom 50%	0.151	0.79	0.57	0.29	0.93
Top 20%	0.322	0.42	0.85	0.38	0.87
Top 15%	0.387	0.32	0.87	0.39	0.85
Top 10%	0.448	0.22	0.93	0.40	0.84

Risk Cutoff, predicted probability of the composite kidney end point; PPV, positive predictive value; NPV, negative predictive value; T2D, type 2 diabetes; APOL1-HR, high-risk APOL1.