TABLE 3.
Multivariable Logistic Regression Model of Incident Postoperative Delirium in Relation to Baseline Characteristics
| Model 1 | Model 2 | Model 3 | Model 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| OR 95% CI | z | p Value | OR 95% CI | z | p Value | OR 95% CI | z | p Value | OR | z | p Value | |
|
| ||||||||||||
| GDS-15 | 1.17 (1.07–1.28) |
3.50 | <0.001 | 1.16 (1.06−1.28) |
3.32 | 0.001 | 1.15 (1.05−1.26) |
2.95 | 0.003 | 1.13 (1.02−1.25) |
2.43 | 0.02 |
| Age | - | - | - | 1.06 (1.01−1.10) |
2.52 | 0.01 | 1.04 (0.10−1.09) |
1.75 | 0.08 | 1.05 (0.99−1.10) |
1.91 | 0.06 |
| Female | - | - | - | 0.83 (0.42−1.64) |
−0.54 | 0.59 | 1.06 (0.51−2.18) |
0.15 | 0.88 | 1.08 (0.47−2.47) |
0.19 | 0.85 |
| Race | - | - | - | 4.17 (0.37−47.42) |
1.15 | 0.25 | 5.78 (0.49−1.66) |
1.39 | 0.16 | 6.49 (0.49−86.69) |
1.41 | 0.16 |
| Education level | - | - | - | 0.95 (0.46−1.96) |
−0.13 | 0.90 | 0.78 (0.36−1.66) |
−0.65 | 0.51 | 0.76 (0.34−1.17) |
−0.66 | 0.51 |
| CCI | - | - | - | - | - | - | 1.12 (0.93−1.34) |
1.21 | 0.23 | 1.11 (0.90−1.36) |
0.97 | 0.33 |
| MMSE | - | - | - | - | - | - | 0.88 (0.79−0.97) |
−2.65 | 0.008 | 0.86 (0.77−0.96) |
−2.73 | 0.006 |
| A 42/p-tau181 | - | - | - | - | - | - | - | - | - | 1.01 (0.89−1.15) |
0.14 | 0.89 |
Model 1 contains univariable regression for GDS-15 and delirium. Model 2 adds demographic variables. Model 3 adds MMSE and CCI variables. Model 4 adds the CSF A 42/p-tau181 variable. Z and p values calculated by linear regression, adjusted for covariates as indicated for each model.
Abbreviations: Aβ42/p-tau181 = CSF amyloid-beta 1–42 to phosphorylated tau181 ratio; CCI, Charlson Comorbidity Index;29 CI, Confidence Interval; Geriatrics Depression Scale-15 (short form)21 (15 items, max. score = 15 points; higher score = worse depression; cut-off score of >5 for depression); MMSE, Mini-Mental State Examination24 (10 items, max. score = 30 points).