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. 2021 Aug 24;47(5):E203–E213. doi: 10.1097/BRS.0000000000004203

Figure 4.

Figure 4

The genes transcription of (A) Piezo1, (B) NLRP3, (C) IL-1β, (D) MMP9, (E) MMP13, (F) TGF-β, (G) Aggrecan, and (H) Col2α1 in the nucleus pulposus cells of the discs in different groups. A, B, Both the Low and High-impact injury caused an up-regulation of the Piezo1 and NLRP3 genes transcription in comparison with the control group, especially in the Low-impact group at day 7 and 14 (P < 0.05). C, The pro-inflammatory (IL-1β) gene transcription was also strongly upregulated in both the Low and High-impact group, especially in the High-impact group at day 7 and in the Low- impact group at day 14 (P < 0.05). D, E, The catabolic (MMP-9, MMP-13) genes transcription were upregulated after impact injury in comparison with the control group, especially in the Low-impact group at day 14 (P < 0.05). F, No significant differences were found in the gene expression of TGF-β between the control and impact injury groups. G, H, The aggrecan and Col2α1 genes transcription were downregulated in both the Low and High-impact groups in comparison with the control group, except at day 7 in the High-impact group.