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Silencing Piezo1 reduced the activation of NLRP3 inflammasome induced by impact injury. A–C, The mRNA and protein expression of IL-1β, NLRP3 in the nucleus pulposus cells exposed to Piezo1-siRNA were significantly downregulated, accompanied by significant upregulation of aggrecan. D, The results of immunofluorescence staining showed that the expression of NLRP3 was downregulated in the nucleus pulposus cells by silencing Piezo1.
