TABLE 2.

Univariate regression of parameters that predict severe COVID-19

Parameter	OR (95% CI)	C-index	P
Traditional predictors
Agea (years)	2.01 (1.30–3.12)	0.64	0.0017
Diabetes mellitus	2.06 (1.08–3.93)	0.58	0.0293
RAAS components
sACE2 (ng/ml)	1.42 (1.21–1.67)	0.68	<0.0001
Renin (pg/ml)	1.23 (1.01–1.51)	0.61	0.04
Aldosterone (pg/ml)	0.61 (0.47–0.79)	0.64	<0.0001
Aldosterone/renin ratio	0.69 (0.57–0.84)	0.68	<0.0001
Polymorphism
TMPRSS2 rs2070788 AA genotype	0.44 (0.21–0.91)	0.59	0.04

Continuous variables were logarithmically transformed (log2). The odds ratio and its associated 95% CI can be interpreted as the odds of developing severe disease when the continuous variable multiplies by 2.

RAAS, renin-angiotensin-aldosterone system; sACE2, soluble angiotensin-converting enzyme-2; TMPRSS2, transmembrane protease, serine 2.

^aInterquartile odds ratio and associated 95% confidence interval was calculated to aid interpretation of the continuous variable age. It is defined as comparing the risk of severe disease at the 75th percentile of the marker value vs. the 25th percentile.