Figure 7.

Hypertrophy and cardiac function with β₂ARKO BMT. A: representative WGA and isolectin B4 staining of hearts from WT and β₂ARKO BMT receiving 1 wk vehicle or isoproterenol infusion. Quantification of cardiomyocyte area (B) and gravimetric analysis (C) of heart weight (HW) normalized to tibia length (TL) for WT and β₂ARKO BMT mice treated for 1 wk with vehicle or isoproterenol. n = 12, two-way ANOVA, *P < 0.05. Quantification of isolectin B4 staining for capillary density for vehicle and isoproterenol-treated WT or β₂ARKO BMT female (D) or male (E) mice. n = 6, two-way ANOVA, *P < 0.05. F: fractional shortening was determined by echocardiography in WT and β₂ARKO BMT animals administered vehicle or isoproterenol. n = 12, two-way ANOVA, *P > 0.05. β₂ARKO BMT, β₂-adrenergic receptor knockout bone marrow transplant; Iso, isoproterenol; NS, not significant; Veh, vehicle; WGA, wheat germ agglutinin; WT, wild-type.