Figure 8.

Summary schematic. The normal heart contains a supply of resident macrophages that helps maintain homeostasis. With an excess of catecholamines, there is proliferation of resident macrophage populations that occurs independent of the β₂AR and recruitment of proinflammatory macrophage populations that is enhanced by β₂AR, which potentiates cardiomyocyte death through the secretion of proinflammatory cytokines, leading to adverse remodeling and disease progression. β₂AR, β₂-adrenergic receptor. Created using Servier Medical Art templates, licensed under Creative Commons Attribution 3.0 Uniported License (https://smart.servier.com).