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. 2022 Feb 4;11:e70207. doi: 10.7554/eLife.70207

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© 2022, Rawle et al

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Figure 5. — (a) 6J mice were infected with chikungunya virus (CHIKV) and then treated with MitoTEMPO or PBS i.v. daily on days 3–8 post infection and foot swelling measured (n = 5/6 mice and 10/12 feet per group). Statistics by t-tests, days 6, 7, and 8, p < 0.001. (b) Viremia for the mice in (a), with an additional group of six mice treated daily with MitoTEMPO from day 0 till day 6. (c) H&E staining of muscle tissues in feet of mice day 6 post CHIKV infection for mice treated with PBS or MitoTEMPO from day 3 to day 6. Clusters of small blue spots in and around the muscle bundles illustrate nuclei of infiltrating leukocytes. (d) Aperio pixel count of blue (nuclear) over red (cytoplasmic) pixels; a measure of leukocyte infiltration (statistics by t-test). (e) H&E staining of feet as in (c) but showing overt subcutaneous edema. (f) Percentage of foot section areas showing overt subcutaneous edema (statistics by t-test).

Figure 5—figure supplement 1. — (a) 6J mice were infected with chikungunya virus (CHIKV) and then treated with MitoTEMPO or PBS i.v. daily on days 3–8 post infection and foot swelling measured (n = 5/6 mice and 10/12 feet per group). Statistics by t-tests, days 6, 7, and 8, p < 0.001. (b) Viremia for the mice in (a), with an additional group of six mice treated daily with MitoTEMPO from day 0 till day 6. (c) H&E staining of muscle tissues in feet of mice day 6 post CHIKV infection for mice treated with PBS or MitoTEMPO from day 3 to day 6. Clusters of small blue spots in and around the muscle bundles illustrate nuclei of infiltrating leukocytes. (d) Aperio pixel count of blue (nuclear) over red (cytoplasmic) pixels; a measure of leukocyte infiltration (statistics by t-test). (e) H&E staining of feet as in (c) but showing overt subcutaneous edema. (f) Percentage of foot section areas showing overt subcutaneous edema (statistics by t-test).