TABLE II.

List biomarkers used in brain models.

Biomarker	Marker of
Nestin170	Neural stem cell and progenitor
Class III β-tubulin and its antibody TUJ171	Premature or differentiated neural cells
Microtubule-associated protein 2 (MAP-2)172	Mature neuron
Gamma aminobutyric acid (GABA) and its enzymes GAD65/67174	Mature interneuron
Tyrosine hydroxylase (TH)175	Mature dopaminergic neurons
Tryptophan hydroxylase (TPH)176	Serotonergic neurons
Choline acetyltransferase (ChAT)177	Differentiated cholinergic mature neurons
Glial fibrillary acidic protein (GFAP)178	Cell death or astroglia injury
Oligodendrocyte transcription (OLIG1 and OLIG2)179	Mature oligodendrocytes
CD11b, CD45180	Microglia cell
CD86, inducible nitric oxide synthase (iNOS)180	M1 microglia cell
Arginase 1 (ARG1), CD206180	M2 microglia