Table III.
Results of Permeability Measurements on PAMPA Platform
| Type of additive | Additive | Additive concentration (μg/mL) | Pe (10−4 cm/sec) | SD | Reference Pe (10−4 cm/sec) | SD | t-test (p value) |
|---|---|---|---|---|---|---|---|
| Surfactants/complexing agents | SDS | 850 | 0.83 | 0.02 | 1.16 | 0.07 | 0.00 |
| Tween 80 | 0.45 | 0.86 | 0.02 | 1.16 | 0.07 | 0.00 | |
| HPβCD | 1386 | 1.21 | 0.05 | 1.16 | 0.07 | 0.42 | |
| Polymers | HMPC 2910 | 212 | 1.22 | 0.06 | 1.16 | 0.07 | 0.60 |
| PVP K90 | 212 | 1.25 | 0.18 | 1.16 | 0.07 | 0.99 | |
| PVP K30 | 212 | 1.31 | 0.15 | 1.11 | 0.07 | 0.06 | |
| HPMC-AS | 212 | 1.28 | 0.10 | 1.11 | 0.07 | 0.01 | |
| Fillers | Sorbitol | 667 | 1.42 | 0.10 | 1.11 | 0.07 | 0.00 |
| Mannitol | 667 | 1.23 | 0.20 | 1.11 | 0.07 | 0.41 | |
| Lactose monohydrate | 667 | 1.39 | 0.06 | 1.16 | 0.07 | 0.02 |