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The effect of empagliflozin on the expression levels of Sestrin2, AMPK, and Nrf2. I/R injury significantly reduced the expression of Sestrin2 (&&p < 0.01), AMPK (&&p < 0.01), and Nrf2 (&&&&p < 0.0001). Treatment with empagliflozin did not significantly change the expression of Sestrin2 and AMPK, while it notably upregulated Nrf2 (∗∗∗p < 0.001).
