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. 2022 Jan 28;2022:2444516. doi: 10.1155/2022/2444516

Table 2.

Structure of platinum nanoparticles and indications in tumor therapy.

Types of drugs Structural formula Mechanism of action Adaptive diseases References
Tolfplatin (cisplatin) graphic file with name BCA2022-2444516.tab2.i001.jpg A COX-2 inhibitor that suppresses the production of PEG2 Breast cancer [72]
Carboplatin graphic file with name BCA2022-2444516.tab2.i002.jpg A COX-2 inhibitor with amino-functionalized polyphosphazene vesicles Carcinoma of ovary [73]
Nedaplatin graphic file with name BCA2022-2444516.tab2.i003.jpg A COX-2 inhibitor with higher plasma concentrations of 5-fluorouracil Esophageal squamous cell carcinoma [74]
Lipoxal (oxaliplatin) graphic file with name BCA2022-2444516.tab2.i004.jpg An inhibitor of DNA synthesis that prevents DNA replication and transcription and causes cell death Gastrointestinal cancers [75]
Lobaplatin graphic file with name BCA2022-2444516.tab2.i005.jpg Inhibit the proliferation of cancer cells and promote apoptosis Small-cell carcinoma [76]
Heptaplatin graphic file with name BCA2022-2444516.tab2.i006.jpg An inhibitor of DNA synthesis that prevents DNA replication and transcription Gastric cancer [77]