Figure 4.

Shift in cecal bile acid concentrations in high-fat/high-sucrose (HF/HS) offspring. A: relative abundance of individual bile acids present in cecal contents of HF/HS and CON offspring. B: ratio of primary to secondary bile acids present in cecal contents of HF/HS and chow (CON) offspring. C: relative expression of Asbt, Mrp2, Mrp3, and Shp in ileum of male HF/HS and CON offspring. D: relative expression of Asbt, Mrp2, Mrp3, and Shp in ileum of female HF/HS and CON offspring. Quantitative data presented as means ± SE with n ≥ 5 in each group and ≥5 separate litters represented in each group. Male and female offspring included in each section unless noted. P values as indicated on graph for t tests. CA, cholic acid; DCA, deoxycholic acid; MCA, muricholic acid; TMCA, tauro-muricholic acid; UDCA, urso-deoxycholic acid. CDCA, chenodeoxycholic acid.