Figure 5.

Recipients of cecal microbiome transplant from high-fat/high-sucrose (HF/HS) offspring develop altered bile acid (BA) homeostasis. A: body weight, liver weight, and liver weight-to-body weight ratio of HF/HS and chow (CON) recipient mice. B: BA pool size in HF/HS and CON recipient mice. C: abundance of individual BAs in liver tissue from HF/HS and CON recipient mice. D: abundance of individual BAs in cecal contents from HF/HS and CON recipient mice. E: ratio of primary to secondary BAs in liver and cecal contents of HF/HS and CON recipient mice. F: relative expression of Cyp7a1 and Cyp8b1 in liver of HF/HS and CON recipient mice. G: relative expression of Nr1h4 and Shp in liver of HF/HS and CON recipient mice. Quantitative data presented as means ± SE with n ≥ 5 in each group with representation from ≥5 litters. All data from male mice receiving cecal microbiome transplantation (CMT) from female donors. P values as indicated on graph for t tests.