Figure 10.

Transfer of microbiome from high-fat/high-sucrose (HF/HS) offspring increases fructose-induced hepatic triglyceride (TG) accumulation and alters hepatic lipid metabolism. A: body weight of HF/HS and chow (CON) recipient mice after fructose diet feeding. B: liver weight of HF/HS and CON recipient mice after fructose diet feeding. C: liver weight-to-body weight ratio of HF/HS and CON recipient mice after fructose diet feeding. D: hepatic triglyceride concentration in HF/HS and CON recipient mice after fructose diet feeding. E: relative expression of transcription factors that control lipid metabolism in liver of HF/HS and CON recipient mice after fructose diet feeding. F: relative expression of lipid metabolism genes with significant or trend toward a change in liver of HF/HS and CON recipient mice after fructose diet feeding. G: relative expression of lipid metabolism genes that are unchanged in liver of HF/HS and CON recipient mice after fructose diet feeding. H: relative expression of lipid transport genes in liver of HF/HS and CON recipient mice after fructose diet feeding. Quantitative data presented as means ± SE with n ≥ 6 in each group and ≥6 separate litters represented in each group. All data from male mice that received cecal microbiome transplantation (CMT) from female donors. P values as noted on each graph for t tests.