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. Author manuscript; available in PMC: 2023 Feb 28.
Published in final edited form as: Cancer Lett. 2021 Dec 11;527:80–94. doi: 10.1016/j.canlet.2021.12.006

Figure 6. The role of sirtuins in controlling the circadian clock and energy metabolism.

Figure 6.

Sirtuins are regulators of energy homeostasis. SIRT1 regulates genes related to the synthesis of peptides and cofactors by controlling CLOCK/Bmal1 circadian transcription factors. The nutrient-dependent activation of SIRT1 regulates energy metabolism by influencing Bmal1 expression through PGC-1α in the suprachiasmatic nucleus. Deacetylation of mitochondrial oxidative enzymes by SIRT3 controls mitochondrial oxidative metabolism. Regulation of chromatin recruitment of CLOCK/Bmal1 via SIRT6 through SREBP1 regulates lipid and carbohydrate metabolism genes. (Created with BioRender.com)